Influence of infectious factors on changes in hormonal indicators in women in the early period of miscarriage

Muхitdinova Kamola Oybekovna; Aleinik Vladimir Aleхseevich; Babich Svetlana Mihaylovna; Negmatshaeva Xabiba Nabievna; Zhuraeva Mohigul Azimovna

doi:10.21744/lingcure.v5nS2.1810

Authors

Muхitdinova Kamola Oybekovna
kamosha.muhitdinova@mail.ru
Andijan State Medical Institute, Andijan, Uzbekistan
Aleinik Vladimir Aleхseevich Andijan State Medical Institute, Andijan, Uzbekistan
Babich Svetlana Mihaylovna Andijan State Medical Institute, Andijan, Uzbekistan
Negmatshaeva Xabiba Nabievna Andijan State Medical Institute, Andijan, Uzbekistan
Zhuraeva Mohigul Azimovna Andijan State Medical Institute, Andijan, Uzbekistan

Keywords:

early pregnancy, genitourinary system, inflammation, interleukins, miscarriage, protease inhibitors, sex hormones

Abstract

The work studied the influence of infectious factors on changes in immunological and hormonal parameters in women who have a full pregnancy without infections of the genitourinary system and women with an infection of the genitourinary system and have miscarriages in the early stages of up to 12 weeks of pregnancy. It was concluded that in women in early pregnancy, the presence of infections of the genitourinary system, with insufficient corrective effect of protease inhibitors and TGF-?1. The formation of a pronounced pro-inflammatory immune response is possible, which can contribute to an imbalance of sex hormones. It manifests itself in a slight decrease in prolactin, FSH, LH, but at the same time a pronounced and reliable decrease in the value of progesterone and an increase in the level of estradiol. Thus, all this can contribute to the unfavorable course of early pregnancy and the development of miscarriages.

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